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HealthBefore embarking on Zhewitra 40 Mg therapy, it's essential to heed certain precautions and warnings. Individuals with a history of cardiovascular disease, liver or kidney impairment, or certain eye conditions should exercise caution and consult with a healthcare professional prior to use. Drug interactions with nitrates, alpha-blockers, and certain antifungal medications can potentiate adverse effects and should be avoided. Furthermore, special consideration should be given to elderly individuals and those with pre-existing medical conditions, as they may be more susceptible to complications.